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For a deeper breakdown of GLP-1 gut side effects, see: "GLP-1 Side Effects and Gut Health." The Hidden Problem: When Slowed Digestion Disrupts Microbial Balance Many GLP-1 users report bloating, constipation, and a general feeling of digestive sluggishness

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Preclinical research shows that some of these receptors are found in the area postrema , a part of the brainstem often called the vomiting center. When you take semaglutide or tirzepatide, this center lights up, signaling to your body that its time to feel nauseous